| Crew: 7 | CDR - Robert L. Gibson |
| Plt - Curtis L. Brown | |
| MS 1 - Mark C. Lee (PLC) | |
| MS 2 - Jerome Apt (EV 1) | |
| MS 3 - N. Jan Davis (EV 2) | |
| MS 4 - Mae C. Jemison | |
| PS 1 - Mamoru Mohri | |
| Launch | 12 September 1992 @ 1023:00.0680 EDT |
| Orbital incl: | 57.00 |
| Max alt: | 312.2 km. |
| Orbits: | 127 |
| Dur: | 7:22:30:24 |
| Landing: | 20 September 1992 @ 0853:24 EDT |
| Launch Window: | 3 hours, 54 minutes (10:23 am - 2:17 pm EDT) limited to 2 hr., 30 min. "Crew on Back" constraint. |
| TAL Sites: | Zaragoza (alternates: Ben Guerir, Morocco and Rota, Spain |
| AOA site: | White Sands |
| Primary landing site: | KSC/SLF (Scheduled - 19 September, 6:59 am EDT) |
| Landing Speed: | 211 knots (243 mph) |
| Landing rollout: | 8,567' from main gear touchdown |
| Vehicle weight @ liftoff: | 4,506,649lbs |
| Orbiter weight @ liftoff: | 244,413 lbs |
| Orbiter weight @ landing: | 219,327 lbs |
| Cargo mass approx.: | 28,158 lbs |
| Landing Weight: | Same |
| Special mission kits: | EMU's, teleprinter, TAGS, Ku-band Antenna, Spacelab Utility Kit, Middeck Utillity Panel, UMS, MADS, MAR, PSA, PLB liner, Bicycle Ergometer, SORG & RMS-303 |
| Spacelab-J - Long Module/Unit #2 | 43 Experiments. Mass - 21,861 lbs |
| GAS Bridge Assembly - mass: 5,000 lbs. 9 GAS canisters & 3 ballast | G-0102, G-0255, G-0300, G-0330, G-0482, G-0520, G-0521, G-0534 & G-0613 |
| Mid-deck | ISAIH (Israel Space Agency Invest. About Hornets), AMOS (see STS-29R), SSCE (see STS-41), SAREX-II (Apt - N5QWL; Mohri - 7L2NJY), UVPI (see STS-45) |
| SSME's: | 2026 (1) - 3rd use, 2022 (2) - 8th use, 2029 (3) - 6th use. At Tower Clear 104% |
| OMS Pods/Engines: | LP-03/105 - Pod 13th use, Motor 11th use & RP-04/108 - Pod 9th use, Motor 13th use |
| ET: | ET-45 (LWT-38) |
| SRB's: | BI-053 (RSRM-26) - Set successfully recovered. |
| Left - ?A | Right - ?B | |||
| 38 | ? | Fwd | ? | 38 |
| 38 | ? | Cyl | ? | 38 |
| 38 | ? | Cyl | ? | 37 |
| TEM5 | ? | Cyl | ? | TEM2 |
| 38 | ? | Cyl | ? | New |
| TEM5 | ? | Cyl | ? | TEM5 |
| 36 | ? | Cyl | ? | 38 |
| 37 | ? | Att | ? | 38 |
| New | ? | Stf | ? | 38 |
| New | ? | Stf | ? | 38 |
| New | ? | Aft | ? | New |
| 22 April 1992 | ET-45 arrives on dock KSC |
| 1 June 1992 | OV-105 returns to OPF-3 following Mission-47/STS-49 |
| 13 July 1992 | ET-45/SRB mate in VAB High Bay 3 |
| 14 July 1992 | SL-J cargo inserted into cargo bay while in OPF-3 |
| 17 August 1992 | OV-105 rollover from OPF-3 to VAB High Bay 3 |
| 20 August 1992 | Orbiter mated to stack (delay due to VAB crane assessment following STS-52 stacking incident) |
| 25 August 1992 | Stack rollout to Pad 39B |
| 28 August 1992 | TCDT countdown dress rehearsal conducted with crew aboard |
| 9 September 1992 | "Call to stations" 43 hr countdown started at 3 am EDT & astronaut arrival at KSC |
| 12 September 1992 | Launch |
| 20 September 1992 | Landing at KSC/SLF (No ferry flight) OV-105 returned to OPF-1 the same day |