| Crew: 6 | CDR - Frederick D. Gregory |
| Plt - Terrence T. Henricks (IV 1) | |
| MS 1 - James S. Voss (EV 2) | |
| MS 2 - F. Story Musgrave | |
| MS 3 - Mario Runco, Jr. (EV 1) | |
| PS 1 - Thomas J. Hennen (DOD) | |
| Launch | 24 November 1991 @ 0644:00.006 EST |
| Orbital incl: | 28.47 |
| Max alt: | 394.3 km. |
| Orbits: | 108 |
| Dur: | 6:22:50:42 |
| Landing: | 1 December 1991 @ 1434:42 PST |
| Launch Window: | 2 hours, 38 minutes (6:31 - 9:09 pm EST) |
| TAL Sites: | Banjul, The Gambia (Alternates - Moron, Spain & Ben Guerir, Morocco) |
| AOA site: | Edwards AFB (Alternates - KSC and WS) |
| Primary landing site: | KSC/SLF, scheduled for 4 December at 2:10 pm EST, runway 15 |
| Landing Speed: | 183 knots (210 mph) |
| Landing rollout: | 11,191' from main gear touchdown |
| Vehicle weight @ liftoff: | 4,526,272 lbs |
| Orbiter weight @ liftoff: | 259,629 lbs |
| Orbiter weight @ landing: | 193,825 lbs |
| Cargo mass approx.: | 44,628 lbs |
| Landing Weight: | 7,010 lbs |
| Special mission kits: | EUM's. Galley, TAGS, teleprinter, Color TV Monitor, Trash Compactor, new HAINS IMU in Position 3, no RMS, and a LBNP (Lower Body Negative Pressure) suit |
| DSP-16/IUS-14 (Defense Support Program satellite Liberty on an IUS - 1991-080B | Deployed mass (DSP/IUS) - 37,618 lbs (DSP mass - 5,200 lbs), USA-75 |
| IOCM | See STS-32R |
| Mid-deck | AMOS-13 (see STS-29R), RME-III-5 (see STS-51A), SAM-4 (STS-28R), Terra Scout (Earth Observations using SpaDVOS - see STS-27R), UVPI (see STS-43), M88-1 Military Man in Space Observations (inclueds: MOSES - Maritime Observation in Space, Battlefield Surveillance from Space (Battleview), Night Mist - Encrypted Communication System and Space Debris Belt Characterization (Space) Experiment), CREAM-2 (see STS-48), Educational Earth Photography and VFT-1 (Visual Function Tester) |
| SSME's: | 2015 (1) - 7th use, 2030 (2) - 6th use, 2029 (3) - 5th use. At Tower Clear 104% |
| OMS Pods/Engines: | LP-01/106 - Pod 7th use, Motor 16th use & RP-01/111 - Pod 7th use, Motor 11th use |
| ET: | ET-53 (LWT-46) |
| SRB's: | BI-047 (RSRM-19) - Set successfully recovered |
| Left - ?A | Right - ?B | |||
| 33 | ? | Fwd | ? | New |
| 33 | ? | Cyl | ? | 33 |
| 33 | ? | Cyl | ? | New |
| 33 | ? | Cyl | ? | New |
| 34 | ? | Cyl | ? | TEM4 |
| 33 | ? | Cyl | ? | 33 |
| 33 | ? | Cyl | ? | TEM2 |
| 33 | ? | Att | ? | 34 |
| 34 | ? | Stf | ? | 34 |
| 33 | ? | Stf | ? | TEM5 |
| 33 | ? | Aft | ? | TEM5 |
| 5 June 1991 | ET-53 arrives on dock KSC |
| 11 August 1991 | OV-104 returns to OPF-2 following Mission-42/STS-43 |
| 27 September 1991 | ET-53/SRB mate |
| 18 October 1991 | OV-104 rollover from OPF-2 to VAB High Bay 3 for stacking the next day |
| 23 October 1991 | Stack rollout to Pad 39A |
| 30 October 1991 | DSP/IUS payload inserted into cargo bay at Pad 39A |
| 1 November 1991 | TCDT countdown dress rehearsa conducted with crew aboard |
| 16 November 1991 | Astronaut arrival KSC for 1st attempt |
| 17 November 1991 | Original "Call to stations" 43 hr countdown started at 12:01 am EST |
| 22 November 1991 | New "Call to stations" 43 hr countdown started at 12:01 am EST & astronaut arrival KSC, for 2nd attempt |
| 24 November 1991 | Launch |
| 1 December 1991 | Landing at EAFB |
| 7 December 1991 | OV-104 departs Dryden on SCA-911 for Shepard AFB for over night stay |
| 8 December 1991 | Orbiter Atlantis departs Shepard AFB for KSC and is towed to OPF-2 the next morning |