| Crew: 7 | CDR - Brewster H. Shaw |
| Plt - Bryan D. O'Connor | |
| MS 1 - Jerry L. Ross (EV 1) | |
| MS 2 - Mary L. Cleave | |
| MS 3 - Sherwood C. Spring (EV 2) | |
| PS 1 - Charles D. Walker | |
| PS 2 - Rudolfo Neri-Vela | |
| Launch | 26 November 1985 @ 1929:00 EST |
| Orbital incl: | 28.47 |
| Max alt: | 381.4 km. |
| Orbits: | 108 |
| Dur: | 6:21:04:50 |
| Landing: | 3 December 1985 @ 1333:49 PST |
| Launch Window: | 9 minutes (7:29 - 7:38 pm EST) |
| TAL Sites: | Dakar |
| AOA site: | Edwards, AFB |
| Primary landing site: | Edwards AFB, scheduled at 3:23 pm PST 3 December |
| Landing Speed: | 189 knots (217 mph) |
| Landing rollout: | 10,759' from main gear touchdown |
| Vehicle weight @ liftoff: | 4,514,530 lbs |
| Orbiter weight @ liftoff: | 261,610 lbs |
| Orbiter weight @ landing: | 205,732 lbs |
| Cargo mass approx.: | 48,041 lbs |
| Landing Weight: | 20,464 lbs |
| Special mission kits: | RMS-301, EMU's 1077, 1070, & 1079 spare, teleprinter, two food warmers, Payload Stowage Assembly and MFR. NOTE: KuBand rendezvous radar removed |
| EASE/ACCESS | Esperimental Assembly of Structures in Extravehicular Activity/Assembly Concept for Construction of Erectable Space Structures - mass (inc. MPESS carrier) - 4,423 lbs |
| HS-376 Morelos-B/PAM-D - 1985-105B | Deployed mass - 7,583 lbs, ASE. Morelos-B mass - 1,437 lbs |
| HS-376 AUSSAT-1B (2)/PAM-D - 1985-105C | Deployed mass - 7,634 lbs, ASE. Aussat-1B mass - 1,322 lbs |
| RCA-Model 4000 Satcom Ku-2/PAM-D2 #1 - 1985-105D | Deployed mass - 12,360 lbs, ASE II Cradle. Satcom-Ku-2 mass - 2,251 lbs |
| OEX Target Satellite - 1985-105E | Deployed by S. Spring on EVA-1 |
| EVA-1 - 29 November | Duration - 5 hours, 34 minutes |
| EVA-2 - 1 December | Duration - 6 hours, 43 minutes |
| Mid-deck | CFES-III (see STS-41D), DMOS (see STS-51A), IMAX Cargo Bay camera for EASE/ACCESS photography, PCG (see STS-51D), Linhof Large Format Camera for African water survey |
| GAS | G-0479 |
| SSME's: | 2011 (1) & 2019 (2)- Both 3rd use, 2017 (3) - 5th use. At liftoff 104% same after throttle-up |
| OMS Pods/Engines: | LP-03/107 - 7th use & RP-99/111 - Pod 8th use, motor 3rd use |
| ET: | ET-22 (LWT-15) |
| SRB's: | LO-23/BI-023 - Lightweight set successfully recovered |
| Left - 23A | Right - 23B | |||
| 12-A | 015 | Fwd | 023 | 12-B |
| 13-A | 024 | Cyl | 038 | 12-B |
| 12-A | 047 | Cyl | 042 | 12-B |
| 12-A | L12 | Cyl | L63 | 12-B |
| 12-B | L56 | Cyl | L102 | New |
| 12-A | L53 | Cyl | L57 | 12-B |
| 12-A | L54 | Cyl | L58 | 12-B |
| 12-A | L09 | Att | L10 | 12-B |
| 12-A | L17 | Stf | L38 | New |
| 13-B | L21 | Stf | L12 | 14-B |
| 12-A | 022 | Aft | 023 | 12-B |
| 4 April 1985 | ET-22 arrives on dock KSC |
| 12 October 1985 | OV-104 returns to the OPF following Mission-21/51-J |
| 23 October 1985 | ET/SRB mate |
| 8 November 1985 | OV-104 rollover from OPF-1 to VAB High Bay 3 for stacking same day |
| 12 November 1985 | Stack rollout to Pad 39A |
| 13 November 1985 | 61-B payload insertion at Pad 39A |
| 14 November 1985 | TCDT dress rehearsal conducted with crew aboard |
| 23 November 1985 | Astronaut arrival KSC |
| 24 Novmeber 1985 | "Call to stations" 43 hr countdown started ta 2 pm EST |
| 26 November 1985 | Launch |
| 3 December 1985 | Landing at Edwards AFB |
| 7 December 1985 | Ferry flight from Edwards AFB to Kelly AFB and on to KSC, on day hop |
| 8 December 1985 | OV-104 delivered to the OPF |